Key publications Massie-team (Neuro-Aging)
Lifespan extension with preservation of hippocampal function in aged system xc−-deficient male mice
Lise Verbruggen, Gamze Ates, Olaya Lara, Jolien De Munck, Agnès Villers, Laura De Pauw, Sigrid Ottestad-Hansen, Sho Kobayashi, Pauline Beckers, Pauline Janssen, Hideyo Sato, Yun Zhou, Emmanuel Hermans, Rose Njemini, Lutgarde Arckens, Niels C. Danbolt, Dimitri De Bundel, Joeri L. Aerts, Kurt Barbé, Benoit Guillaume, Laurence Ris, Eduard Bentea & Ann Massie Mol Psychiatry 27, 2355–2368 (2022). https://doi.org/10.1038/s41380-022-01470-5
Aged xCT-Deficient Mice Are Less Susceptible for Lactacystin-, but Not 1-Methyl-4-Phenyl-1,2,3,6- Tetrahydropyridine-, Induced Degeneration of the Nigrostriatal Pathway
Bentea Eduard, De Pauw Laura, Verbruggen Lise, Winfrey Lila C., Deneyer Lauren, Moore Cynthia, Albertini Giulia, Sato Hideyo, Van Eeckhaut Ann, Meshul Charles K., Massie Ann. Frontiers in Cellular Neuroscience. DOI: 10.3389/fncel.2021.796635
Chronic Sulfasalazine Treatment in Mice Induces System xc- - Independent Adverse Effects
Lise Verbruggen, Lindsay Sprimont, Eduard Bentea, Pauline Janssen, Azzedine Gharib, Lauren Deneyer, Laura De Pauw, Olaya Lara, Hideyo Sato, Charles Nicaise, Ann Massie
Corticostriatal dysfunction and social deficits in mice lacking the cystine/glutamate antiporter.
E. Bentea, A. Villers, C. Moore, A.J. Funk, S.M. O’Donovan, L. Verbruggen, O. Lara, P. Janssen, L. De Pauw, N.B. Declerck, E.A.K. DePasquale, M.J. Churchill, H. Sato, E. Hermans, L. Arckens, C.K. Meshul, L. Ris, R.E. McCullumsmith, A. Massie. Molecular Psychiatry (2020) doi: 10.1038/s41380-020-0751-3.
Anticonvulsant and antiepileptogenic effects of system xc- inactivation in chronic epilepsy models.
K. Leclercq*, J. Van Liefferinge*, G. Albertini, M. Neveux, S. Dardenne, G. Mairet-Coello, C. Vandenplas, T. Deprez, S.-A. Chong, P. Foerch, E. Bentea, H. Sato, P. Maher, A. Massie*, I. Smolders*, R. Kaminski*. Epilepsia (2019) 60: 1412-23. (* equally contributing authors)
Genetic deletion of xCT attenuates peripheral and central inflammation and mitigates LPS-induced sickness and depressive-like behavior in mice.
G. Albertini, L. Deneyer, S. Ottestad-Hansen, Y. Zhou, G. Ates, L. Walrave, T. Demuyser, E. Bentea, H. Sato, D. De Bundel, N.C. Danbolt, A. Massie*, I. Smolders*. GLIA (2018) 66, 1845-1861. (* equally contributing authors)
Comparative analysis of antibodies to xCT (Slc7a11) : forewarned is forearmed.
J. Van Liefferinge, E. Bentea, T. Demuyser, G. Albertini, V. Follin-Arbelet, S. Holmseth, E. Merckx, H. Sato, J. Aerts, I. Smolders, L. Arckens, N.C. Danbolt, A. Massie. Journal of Comparative Neurology (2016) 524, 1015-32.
Dopaminergic neurons of system xc- deficient mice are highly protected against 6-OHDA induced neurodegeneration.
A. Massie, A. Schallier, S.-W. Kim, R. Fernando, S. Kobayashi, H. Beck, D. De Bundel, K. Vermoesen, S. Bannai, I. Smolders, M. Conrad, N. Plesnila, H. Sato, Y. Michotte. FASEB Journal (2011) 25: 1359-69.
Loss of system xc- does not induce oxidative stress but decreases extracellular glutamate in hippocampus and influences spatial working memory and limbic seizure susceptibility.
D. De Bundel*, A. Schallier*, E. Loyens, R. Fernando, H. Miyashita, J. Van Liefferinge, K. Vermoesen, S. Bannai, H. Sato, Y. Michotte, I. Smolders*, A. Massie*. Journal of Neuroscience (2011) 31: 5792-803. (* equally contributing authors)
ORCID Ann Massie
Key publications Aerts-team (Viro-immunology)
Autologous dendritic cell vaccination against HIV-1 induces changes in natural killer cell phenotype and functionality
Thessa Laeremans, Sabine den Roover, Cynthia Lungu, Sigrid D’haese, Rob A. Gruters, Sabine D. Allard & Joeri L. Aerts. npj Vaccines volume 8, Article number: 29 (2023). doi: https://doi.org/10.1038/s41541-023-00631-z.
Oncolytic Herpes Simplex Virus Type 1 Induces Immunogenic Cell Death Resulting in Maturation of BDCA-1 + Myeloid Dendritic Cells
Kalus P, De Munck J, Vanbellingen S, Carreer L, Laeremans T, Broos K, Dufait I, Schwarze JK, Van Riet I, Neyns B, Breckpot K, Aerts JL. Int J Mol Sci. 2022; 23(9):4865. doi: 10.3390/ijms23094865.PMID: 35563257
Off the beaten path: Novel mRNA-nanoformulations for therapeutic vaccination against HIV.
D'haese S, Lacroix C, Garcia F, Plana M, Ruta S, Vanham G, Verrier B, Aerts JL. J control release. 2020 Nov 10:S0168-3659(20)30658-1.
Rapid viral rebound after analytical treatment interruption in patients with very small HIV reservoir and minimal on-going viral transcription.
Pannus P, Rutsaert S, De Wit S, Allard SD, Vanham G, Cole B, Nescoi C, Aerts J, De Spiegelaere W, Tsoumanis A, Couttenye MM, Herssens N, De Scheerder MA, Vandekerckhove L, Florence E. J Int AIDS Soc. 2020 Feb;23(2):e25453.
Intranodal administration of mRNA encoding nucleoprotein provides cross-strain immunity against influenza in mice.
Joe PT, Christopoulou I, van Hoecke L, Schepens B, Ysenbaert T, Heirman C, Thielemans K, Saelens X, Aerts JL. J Transl Med. 2019 Jul 25;17(1):242.
Immune checkpoint blockade combined with IL-6 and TGF-β inhibition improves the therapeutic outcome of mRNA-based immunotherapy.
Bialkowski L, Van der Jeught K, Bevers S, Tjok Joe P, Renmans D, Heirman C, Aerts JL, Thielemans K. Int J Cancer. 2018 Aug 1;143(3):686-698
Preclinical evaluation of an mRNA HIV vaccine combining rationally selected antigenic sequences and adjuvant signals (HTI-TriMix).
Guardo AC, Joe PT, Miralles L, Bargalló ME, Mothe B, Krasniqi A, Heirman C, García F, Thielemans K, Brander C, Aerts JL, Plana M; iHIVARNA consortium. AIDS. 2017 Jan 28;31(3):321-332.
Axitinib increases the infiltration of immune cells and reduces the suppressive capacity of monocytic MDSCs in an intracranial mouse melanoma model.
Du Four S, Maenhout SK, De Pierre K, Renmans D, Niclou SP, Thielemans K, Neyns B, Aerts JL. Oncoimmunology. 2015 Jan 22;4(4):e998107.
Enhanced suppressive capacity of tumor-infiltrating myeloid-derived suppressor cells compared with their peripheral counterparts.
Maenhout SK, Van Lint S, Emeagi PU, Thielemans K, Aerts JL. Int J Cancer. 2014 Mar 1;134(5):1077-90.